gad 65造句

• GAD 67 and GAD 65 are also regulated differently post-translationally.
• GAD 67 is spread evenly throughout the cell while GAD 65 is localized to nerve terminals.
• These isoforms are GAD 67 and GAD 65 with molecular weights of 67 and 65 kDa, respectively.
• GAD 67 is transcribed during early development, while GAD 65 is not transcribed until later in life.
• Injections with GAD 65 has been shown to preserve some insulin production for 30 months in humans with type 1 diabetes.
• Both GAD 67 and GAD 65 are targets of autoantibodies in people who later develop type 1 diabetes mellitus or latent autoimmune diabetes.
• GAD 65 and GAD 67 synthesize GABA at different locations in the cell, at different developmental times, and for functionally different purposes.
• Both GAD 65 and GAD 67 are regulated via phosphorylation, but the regulation of these isoforms differs; GAD 65 is activated by phosphorylation while GAD 67 is inhibited by phosphorylation.
• Both GAD 65 and GAD 67 are regulated via phosphorylation, but the regulation of these isoforms differs; GAD 65 is activated by phosphorylation while GAD 67 is inhibited by phosphorylation.
• GAD 67 is phosphorylated at threonine 91 by protein kinase A ( PKA ), while GAD 65 is phosphorylated, and therefore regulated by, protein kinase C ( PKC ).
• Peripheral nerve injury of the sciatic nerve ( a neuropathic pain model ) induces a transient loss of GAD 65 immunoreactive terminals in the spinal cord dorsal horn and suggests a potential involvement for these alterations in the development and amelioration of pain behaviour.
• This developmental difference in GAD 67 and GAD 65 reflects the functional properties of each isoform; GAD 67 is needed throughout development for normal cellular functioning, while GAD 65 is not needed until slightly later in development when synaptic inhibition is more prevalent.
• This developmental difference in GAD 67 and GAD 65 reflects the functional properties of each isoform; GAD 67 is needed throughout development for normal cellular functioning, while GAD 65 is not needed until slightly later in development when synaptic inhibition is more prevalent.
• This reflects the functional properties of the two isoforms; GAD 67 must be active at all times for normal cellular functioning, and is therefore constantly activated by PLP, while GAD 65 must only be activated when GABA neurotransmission occurs, and is therefore regulated according to the synaptic environment.
• Both GAD 67 and GAD 65 are also regulated post-translationally by Pyridoxal 5-phosphate ( PLP ); GAD is activated when bound to PLP and inactive when not bound to PLP . Majority of GAD 67 is bound to PLP at any given time, whereas GAD 65 binds PLP when GABA is needed for neurotransmission.
• Both GAD 67 and GAD 65 are also regulated post-translationally by Pyridoxal 5-phosphate ( PLP ); GAD is activated when bound to PLP and inactive when not bound to PLP . Majority of GAD 67 is bound to PLP at any given time, whereas GAD 65 binds PLP when GABA is needed for neurotransmission.